Using mitochondrial Ca2+ Uptake as a Therapeutic Target for Amyotrophic Lateral Sclerosis (ALS)

Time: 11:45 am
day: Day One


• Determine the contribution of skeletal muscle in ALS pathogenesis
• Characterize the progression of ALS in a mouse model using comprehensive longitudinal studies
• Explore the therapeutic potential of inhibiting mitochondrial Ca2+ uptake in ALS mice using a newly-generated inducible genetic mouse model (Genetic intervention)
• Assess the protective effect of a mitochondrial uncoupler (indirectly inhibit mitochondrial Ca2+ uptake), MP101/MP201, in a ALS mouse model (Pharmacological intervention)