Small Molecule Activator of PINK1 in Preclinical Models of Parkinson’s Disease & Mitochondrial Disease

Time: 3:30 pm
day: Day One


  • Examining the discovery and optimization of small molecule activator of PINK1, MTK458
  • Exploring how MTK458 reduces mitochondrial damage signature in multiple orthogonal models of mitochondrial disease and Parkinson’s disease
  • Demonstrating pathological and functional rescue in pre-clinical alpha synuclein PFF model of Parkinson’s disease